Creatine and Creatinine. 



4i 



Table II shows what may be called the Coagulation Equilibrium 

 test. This is performed by adding the antithrombin of the test 

 case to its own plasma instead of to the plasma of a normal case. 

 This tells us how delicately the coagulation is balanced. For 

 example in Table II, which is the plasma of the same hemophilia 

 case as in Table I, we see that the coagulation time is markedly 

 delayed by the addition of its own antithrombin. This is not 

 due to an excess of antithrombin, as we have seen from Table I, 

 but simply means that the plasma is in a very stable condition 

 and that a slight excess of antithrombin will prevent its coagula- 

 tion. If this coagulation equilibrium-test turns out negatively 

 and there is little delay, it serves at the same time as a test for 

 antithrombin and we may deduce that this substance is not 

 increased. 



table 11. 



Equilibrium Test. 



Control 



3 Anti. 



5 Anti. 











6 min. 



+ 



+ 



+ 



10 " 



+ + + 



+ 



+ 



12 " 





+ + + 



+ ' 



IS " 







+ + 



35 " 







+ + + 



43 " 



24 (956) 



Studies on the relationship between creatine and creatinine. 



By V. C. Myers and M. S. Fine. 



[From the Laboratory of Pathological Chemistry, New York Post- 

 Graduate Medical School and Hospital.} 



When muscle tissue is allowed to autolyze, creatine is trans- 

 formed to creatinine at a constant rate. The velocity of this 

 reaction increases with a rise in temperature, although practically 

 negligible at o° C. The rate of formation at body temperature 

 is nearly sufficient to account for the daily elimination of creatinine. 

 The velocity of the reaction is increased by acids but not reduced 

 by Henderson's neutral phosphate mixture. Added creatine expe- 

 riences the same fate as the creatine originally present, while 



