42 



Scientific Proceedings (62). 



added creatinine inhibits the reaction, or if added in sufficient 

 quantity causes it to proceed in the opposite direction. Pure 

 solutions of creatine and creatinine experience the same trans- 

 formations, although much more slowly. On the long standing 

 of pure solutions there seems to be a slight loss in total creatinine 

 (from both creatine and creatinine). This appears to be due in 

 part to a transformation to urea. Whether or not these phe- 

 nomena are vital factors in the formation of creatinine in the 

 body, we are unprepared to say. 



To obtain further light on this point, experiments have been 

 conducted on nephrectomized animals. The creatine and creati- 

 nine content of the various body tissues have been determined 

 several days after a double nephrectomy. In certain of these 

 experiments creatine and creatinine have been injected. Some- 

 what similar deductions may be drawn from our experiments in 

 vivo to those in vitro; although there are certain differences be- 

 tween the two types of experiments, the significances of which are 

 not as yet entirely clear to us. 



25 (957) 



Statistics of pellagra in Spartanburg County. 



By J. F. Siler, P. E. Garrison and W. J. MacNeal. 



[From the Robert M. Thompson Pellagra Commission of the New 

 York Post-Graduate Medical School and Hospital.] 



Up to September 15, 1914, we have recorded about 1,165 cases 

 of pellagra, which have been recognized in Spartanburg County, 

 S. C, the large bulk of them since 1910. The population of this 

 county in 1910 was 84,000. The comparative study of the dis- 

 tribution of that portion of these cases recorded up to the end of 

 1913, in respect to geographical location, race, age, sex and occupa- 

 tion, has shown the disease to be most prevalent in the larger 

 centers of population and especially in the cotton-mill villages. 

 Pellagra has been about three times as prevalent among the white 

 population as in the negroes. It was very rare in children under 

 the age of two, uncommon in the five years following puberty in 

 both sexes, and only slightly prevalent in adult males under fifty 



