Hyaline Casts in Dogs. 



59 



A similar difference was observed also in nephrectomized dogs. 



It is claimed by some investigators that the glycemia following 

 depancreatization is due to an over-production of sugar. It is 

 evident that the hyperglycemia in our cases of depancreatization 

 can not be due to such a factor. We shall not discuss here whether 

 our results can be adequately explained by the assumption that 

 the removal of the pancreas causes a decrease of consumption 

 of dextrose by the body tissues. We wish, however, to indicate 

 that some of our facts hint at the possibility of a change in the 

 permeability of the endothelia of the circulatory apparatus as a 

 factor in the results of depancreatization. 



38 (970) 



The influence of the intra-intestinal administration of magnesium 

 sulphate on the production of hyaline casts in dogs. 



By F. L. Gates. 



[From the Department of Physiology and Pharmacology of the Rocke- 

 feller Institute for Medical Research.] 



Following our study of hyaline cast production after the intra- 

 muscular or intravenous injection of hydrated magnesium sulphate 

 and certain other salts, reported to this society in February and 

 June of this year, 1 Dr. Meltzer suggested that the investigation be 

 carried further by a series of experiments in which the MgSC»4 

 was given directly into the intestines, simulating its use as a 

 purgative. 



The typical procedure in the present series was to inject an m/l 

 solution of hydrated MgS0 4 , in doses of .18 or .2 gm. per kilo, 

 body weight, through a glass cannula into the upper duodenum. 

 The small intestine was isolated by ligatures just below the 

 pylorus and at the ileo-cecal valve. The operation was per- 

 formed under complete ether anesthesia and the dogs were killed 

 at the end of five or six hours. For two animals the solution was 

 diluted to ra/3 before injection and in three other cases the ligature 

 was not placed at the ileo-cecal valve. In each case control urines 

 were examined for casts and albumin. 



1 Proc. Soc. Exp. Biol, and Med.. Vol. XI, No. 3 (879); Vol. XI, No. 6 (919). 



