6o 



Scientific Proceedings (63). 



Of twelve dogs in this series ten showed hyaline casts after 

 the magnesium injection; in eight the casts were abundant. 

 They were usually accompanied by a trace of albumin. The 

 casts were most numerous in the two to three hour period, but 

 usually persisted in small numbers until the end of the experiment. 

 Gross examination of the kidneys revealed no significant changes. 



The general effects of the absorbed magnesium appeared in 

 dullness and relaxation, partial or complete anesthesia and paral- 

 ysis, and in one case in a typical "magnesium death" from re- 

 spiratory paralysis. 



39 (97i) 



Distribution of solutions in cardiectomized frogs with destroyed 

 or inactive lymph hearts. 



By T. S. Githens and S. J. Meltzer. 



[From the Department of Physiology and Pharmacology of the Rocke- 

 feller Institute for Medical Research.] 



It has been assumed, in various communications from this 

 laboratory, 1 that the distribution of solutions in cardiectomized 

 frogs takes place by way of a peripheral mechanism. Abel, 2 

 stated later emphatically that this distribution occurs by the 

 pumping activities of the anterior lymph hearts, stating himself, 

 at the same time, that it would be impossible for the posterior 

 lymph hearts to accomplish such an effect. In opposition to 

 Abel's statement, we demonstrated a year ago, 3 at a meeting 

 of this society, that strychnin is capable of producing convulsions 

 in cardiectomized frogs from which the anterior lymph hearts 

 were previously removed. In a recent paper by Abel, 4 he admits 

 the correctness of our contention that strychnin, etc., may become 

 effective even in cardiectomized frogs without anterior lymph 

 hearts. But now he assumes that the distribution is carried on by 



1 Jour, of Exp. Medicine, Vol. 13, 1911, p. 542; Proc. of Royal Society, B. Vol. 

 84, p. 99; Proc. of Soc. for Exp. Biol, and Medicine, Vols. 8 and 9. 



2 Abel, Jour, of Pharmacology and Exp. Therapeutics, Vol. 3, 1912, p. 581. 



3 Githens and Meltzer, Proc. of Soc. for Exp. Biol, and Medicine, Vol. II, 

 p. 96. 



4 Abel and Turner, Jour, of Pharm., Vol. 6, p. 91, 1914. 



