Pulse Form of Febrile Patients. 



61 



the posterior lymph hearts through some delicate collateral vessels. 

 He is again emphatic in his denial of the possibility of distribution 

 through a peripheral mechanism. 



In the last few months we have made several series of experi- 

 ments on completely eviscerated frogs from which all the four 

 lymph hearts were positively excluded. Thoroughly eviscerated 

 frogs in which in addition the four lymph hearts are especially 

 destroyed, are exposed to extreme shock, which profoundly affects 

 the nervous system. Nevertheless, we have observed in a goodly 

 number of these animals the definite appearance of characteristic 

 tetanic convulsions or of unmistakable hyperesthesia after in- 

 jections of strychnin. 



In another series of cardiectomized frogs which were left on ice 

 for several days, adrenalin was injected into the thigh in doses from 

 I mg. to o.i mg. In all of these cases definite dilatation of the 

 pupils was obtained — a well-known characteristic reaction to 

 adrenalin. The time before the first effect was noticed varied 

 from ten to thirty minutes. Since the lymph hearts stop beating 

 in a comparatively brief time after cardiectomy, especially when 

 the animals are kept on ice, the distribution of the adrenalin from 

 the thigh to the orbit several days after cardiectomy could not 

 have taken place by the aid of the lymph hearts. 



40 (972) 



The effect of pituitary substance upon the pulse form of febrile 



patients. 



By A. W. Hewlett. 



[From the Department of Internal Medicine, University of Michigan.] 



In a recent study of dicrotic and monocrotic pulse forms it 

 was shown that these are always accompanied by a transient 

 backward movement of the blood column in the brachial artery 

 just after the entrance of the primary pulse wave. This backward 

 movement may be due either to local conditions in the arm which 

 permit an unusual reflection of the pulse wave or to conditions 

 elsewhere in the cardiovascular apparatus which permit the re- 

 flected wave, itself perhaps normal, to become evident on our 



