7 6 



Scientific Proceedings (64). 



from the horse. The tubes which came from the sensitized in- 

 dividuals presented a distinct response upon the addition of minute 

 amounts of horse serum, while the controls failed to respond even 

 on the addition of large amounts of horse serum. The contractile 

 response, although much less pronounced than in the case of the 

 guinea-pig, is still unmistakable. The response to ergamine, 

 adrenalin, and other similar drugs, is also very much less marked, 

 in the case of the human preparation. From an anaphylactic 

 standpoint, the human smooth muscle is, therefore, intermediate 

 between that of the guinea-pig and that of the rabbit. This fact 

 explains the character of the anaphylactic symptoms which have 

 been observed in human beings. 



51 (983) 



The cerebellum in cases of lowered blood pressure and "shock," 

 an experimental study. 



By Alfred Reginald Allen, M.D. (Philadelphia, Pa.). 



[From the Department of Neuropathology, University of Pennsylvania 

 and from the Department of Physiology, University and Bellevue 

 Hospital Medical College, New York City, N. Y.] 



The concept of the histology of the Purkinje cell held today 

 by many neuropathologists is but slightly if at all advanced beyond 

 the classification enunciated by Nissl in 1897. 



As an introduction to the following work it was necessary to 

 make an investigation of the Purkinje cell in normal animals 

 employing different methods of fixation and staining. It seems 

 desirable therefore not only to state my own views as to classi- 

 fication but also to briefly outline the technique used. 



Although monkeys (Macacus rhesus), rabbits, cats and dogs 

 were used in this histological study yet the conclusions in this 

 presentation are drawn altogether from the dog. 



The animals were all well fed and young. No animal was 

 used which was not in good health. Care was taken to exclude 

 the factor of physical exhaustion. No animal was brought in a 

 shrinking or terrified condition to the operating room. When 



