Influence of Nocuous Stimuli in Shock. 



83 



quickly the cortex of the brain and the lateral columns of the cord 

 lost their faradic excitability in severe hemorrhage. Let us re- 

 member this point in considering P. 4, P. 6, P. 7 and P. 8. 



The second point to bear in mind is the severity of the stimuli 

 in P. 2. 



My conclusions are therefore as follows: 



1. Lowered blood-pressure and peripheral trauma such as 

 caused by surgical operations under anesthesia have no demonstra- 

 ble effect on the Purkinje cells of the cerebellum. 



2. The syndrome known as "shock" is totally unconnected 

 with any demonstrable change in the Purkinje cells of the cere- 

 bellum. 



52 (984) 



The influence of nocuous stimuli in the production of shock, and 

 the failure of this influence to support the anoci theory 

 of shock. 



By H. H. Janeway, M.D. 



[From the Department of Physiology, University and Bellevue 

 Hospital Medical College.] 



The experiments reported in this communication have been 

 performed for the purpose of investigating the influence of nocuous 

 stimuli in the production of shock, by comparing with controls the 

 shock-producing effect of severe and prolonged electrical stimula- 

 tion to the peripheral sensory nerves in animals rendered 

 susceptible to shock-producing influences by a reduction of their 

 blood pressure. 



Although an animal may be in severe shock with a high blood 

 pressure, yet a fall of blood pressure always occurs before death 

 and may be regarded as the most striking characteristic of shock. 

 A diminution of blood pressure may, therefore, be legitimately 

 considered to favor the development of shock, in other words, 

 to render an animal a more sensitive test-subject upon which to 

 investigate shock-producing influences. Such a method of ex- 

 perimentation would avoid the difficulty in estimating different 

 degrees of shock in the experimental animals and would permit 



