SCIENTIFIC PROCEEDINGS. 



Abstracts of Communications. 



Sixty-fifth meeting. 



College of the City of New York, February 17, 1915. President Lusk 



in the chair. 



58 (990) 



The influence of sodium salicylate upon the uric acid concentration 



of the blood. 



By M. S. Fine and A. F. Chace. 



[From the Laboratory of Pathological Chemistry and the Department 

 of Medicine of the New York Post-Graduate Medical School 

 and Hospital.] 



That the increased output of uric acid following the use of 

 atophan is accompanied by a diminution in the concentration of 

 uric acid in the blood appears to be well established. As has been 

 long known, salicylates induce an increased elimination of uric 

 acid quite comparable to that produced by atophan; and it is of 

 interest to learn whether this urinary increase is accompanied by 

 a commensurate decrease in the blood. 



We have found in seven cases that sodium salicylate in daily 

 doses of 6 grams reduced the uric acid concentration of the blood 

 to one half to one third of the initial concentrations. 



95 



