SCIENTIFIC PROCEEDINGS. 



Abstracts of Communications. 

 Sixty-sixth Meeting. 

 Pathological Laboratory, Bellevue Hospital, March 17, 191 5. 

 President Lush in the chair. 



71 (1003) 

 Tissue juice as a hemostatic. 

 By Alfred F. Hess. 



[From the Research Laboratory, Board of Health, New York City.] 



A very potent hemostatic can be prepared by extracting 

 various tissues with salt solution. The most suitable in this 

 regard is the brain, and somewhat less efficacious, liver or muscle 

 tissue. Thromboplastic substance obtained in this way has very 

 marked power when added to oxalated plasma or to blood, bringing 

 about a clot with almost explosive rapidity. It can be maintained 

 in a sterile condition by means of the addition of 0.3 per cent, 

 tricresol, and in this state has been found to maintain its efficacy 

 for at least a month. This preparation when tested locally upon 

 animals, markedly diminishes the bleeding. In true hemophilia 

 of man, which is characterized by delayed clotting of the blood, 

 in two cases it checked the bleeding when applied locally after 

 numerous other procedures had failed. It seems to be especially 

 adapted for use in such cases. 



When given intravenously to animals, it causes a shortening 

 of the coagulation time. The blood when caught into the usual 

 amount of 1 per cent, oxalate solution, does not remain fluid. A 

 2 per cent, solution of this preparation has been injected intra- 

 venously into human beings and found to decrease the clotting 

 time. 



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