The Absorption and Elimination of Chenopodium. 131 



the initial dose, in others, however, only after the two or more 

 doses were given. Larger doses, 0.04 to 0.08 c.c. per kilo, produced 

 apnea in cats and dogs for a variable period, which was followed 

 by very slow respiration. 



78 (1010) 



The absorption and elimination of chenopodium. 

 By William Salant and A. E. Livingston. 



[From the Pharmacological Laboratory, Bureau of Chemistry, U. S. 

 Department of Agriculture, Washington, D. C] 



The introduction of chenopodium into the stomach or small 

 intestine of different animals after previously ligating the duo- 

 denum immediately below the pylorus was frequently followed 

 by the appearance of symptoms of chenopodium poisoning. 



In rabbits evidence of absorption from the stomach was 

 obtained in some cases after 40 to 95 minutes. In others, how- 

 ever, several hours have elapsed without showing any effects. 

 Absorption from the small intestine was particularly rapid in cats. 

 When 2 to 5 c.c. of the oil was emulsified and introduced into the 

 duodenum symptoms appeared in some individuals almost im- 

 mediately after, in others there was a delay of five minutes. 

 Absorption of chenopodium from the stomach also takes place 

 in cats but the process is much slower. The effect of cheno- 

 podium poisoning was noticed one and three quarter hours after 

 its introduction into the stomach in some experiments, but in 

 other cases no evidence of absorption could be obtained during 

 the lapse of this interval of time. Experiments on dogs indicate 

 that the absorption of chenopodium is much slower in these 

 animals than in cats. 



When chenopodium was given intravenously its presence in 

 the expired air could be easily detected. The odor was especially 

 marked after large quantities were injected. The urine and bile 

 showed no evidence of chenopodium. 



