The Effect of Phlorhizin on Tumors in Animals. 135 



from Veratrum album. Each dose was given in one to three glasses 

 of water, and usually no gastric irritation resulted. However, all 

 patients complained of fullness and throbbing in the head when 

 the pulse rate reached its minimum. The following conclusions 

 appeared to be justified from the data thus far obtained. 



1. The therapeutically effective dose of the tincture of vera- 

 trum album for adults ranges from 30 to 75 minims (administered 

 in doses of 10 to 15 minims, an hour apart). 



2. Clinically, the effects of veratrum resemble the pharmaco- 

 logical, and consist of a slowing of the pulse rate amounting to 12 

 to 42 beats per minute and a fall of systolic blood pressure amount- 

 ing to about 39 mm. ; of the diastolic 32 mm. The two hypertonus 

 cases showed an average systolic fall of 49 mm. ; of diastolic 8.5 mm. 



3. The circulatory effects produced by veratrum take place 

 independently of the "toxic" symptoms, such as nausea and vomit- 

 ing. 



81 (1013) 



The effect of phlorhizin on tumors in animals. 



By F. C. Wood and E. H. McLean. 



[From Columbia University, George Crocker Special Research Fund, 

 F. C. Wood, Director.} 



In 1914 Benedict and Lewis 1 reported the cure of malignant 

 tumors in rats by the induction of glycosuria by phlorhizin. 

 During the past few months similar experiments have been carried 

 on in the laboratory of the Crocker Fund, using the same tumor — 

 Buffalo rat sarcoma — and a progressively growing, highly malig- 

 nant mouse carcinoma. In addition, seven mice bearing spon- 

 taneous tumors have been treated. The treated animals were 

 kept on a diet of meat and lard, as in the experiments of Benedict 

 and Lewis. The rats received subcutaneously 0.003 gram phlor- 

 hizin in olive oil, and the mice 0.001 gram, at two or three day 

 intervals; and the collected urines were examined frequently at 

 the end of the second or third day after injection, and found to 

 give positive Fehling reaction. 



1 Proc. Soc. Exper. Biol, and Med., 1914, xi, 134. 



