Tumor-Like Growths in Rat Stomach. 161 



the process of calcification. It is furthermore shown that the 

 endothelial cells of the capillaries of the lungs have the property 

 of splitting fats and liberating the fatty acid radical. By micro- 

 chemical means the stages in the process may readily be followed. 



As the fat within the endothelial cells has been phagocyted 

 and lies in vacuoles in the protoplasm where it is acted upon by 

 lipolytic secretions of the cell, it differs but little, in relation to cell 

 activity, from fatty deposits which are extracellular and are 

 acted upon by lipases present in the serum. In other words, the 

 phagocyted fat of endothelial cells has an entirely different bearing 

 to the cell from the accumulation of fats in fatty degeneration. 



Our present findings are in perfect accord with the views 

 we have formerly expressed upon the process of pathological 

 calcification. 



95 (1027) 



Tumor-like growths in rat stomach following irritation. 



By F. D. Bullock and G. L. Rohdenburg. 



[From Columbia University, George Crocker Special Research Fund, 

 F. C. Wood, Director.} 



Fibiger's announcement of the production of carcinoma in the 

 rat stomach through the agency of nematodes has not as yet 

 been controverted. We wish briefly to record the fact that 

 somewhat similar pictures can be produced by other means 

 of irritation. By suspending in the stomach cavity woolen balls 

 saturated with chemical irritants or by injecting the chemical 

 irritants into the wall itself, polypoid growths of stratified squam- 

 ous epithelium can be produced. By using celluloid balls with 

 spinous processes these polypoid growths can be made to reach 

 considerable dimensions. When these irritants are applied to the 

 glandular portions of the organ, marked localized thickenings of 

 the mucosa are produced. The chemical irritants cause a marked 

 downgrowth of stratified epithelium resembling the cancroid type 

 described by Fibiger, while the mechanically induced prolifera- 

 tions are characterized by a marked overgrowth of the cornified 

 layers and relatively slight downgrowth. In the glandular por- 



