Scientific Proceedings (67). 



tions of the organ the proliferation under chemical irritation 

 assumes the character of a cystadenoma which involves the 

 stomach wall to a considerable depth. 



96 (1028) 



The inhibition of peristalsis by the oil of chenopodium. 



By William Salant and C. W. Mitchell. 



[From the Pharmacological Laboratory, Bureau of Chemistry, U. S. 

 Department of Agriculture, Washington, D. C] 



Most of the observations were made on isolated segments of 

 intestine taken from different animals and placed in Locke's 

 solution through which a constant stream of oxygen was allowed 

 to pass. Oil of chenopodium added to Locke's solution produced 

 a marked decrease of contractility. An emulsion of 1 : 10,000 

 oil of chenopodium decreased the force and frequency of the 

 contractions soon after the gut was exposed to the oil. When 

 subjected to the influence of oil of chenopodium for a short time, 

 10 to 15 minutes, recovery, though incomplete, took place if at 

 the end of this time it was returned to Locke's solution alone. 

 When the tissue remained longer in contact with the oil, recovery 

 was slight if Locke's solution was substituted for an emulsion con- 

 taining oil of chenopodium. The depressing effect of chenopodium 

 was found to vary in different portions of the gut, being much 

 more marked in case of the colon than in segments taken from 

 the small intestine. 



The intravenous injection of chenopodium given in the form of 

 an emulsion with neutral olive oil or cocoanut oil and acacia in- 

 hibited peristalsis. One tenth to 0.125 c.c. of the oil of chenopodium 

 was followed by decreased frequency of peristaltic action and in 

 some experiments the administration of 0.125 t0 02 c - c - P er kilo 

 completely abolished the movements of the cecum for a consider- 

 able period of time. 



