176 



Scientific Proceedings (67). 



106 (1038) 



Comparative physiology of immune and anaphylactic smooth 

 muscle. (Preliminary communication.) 



By William H. Moore (by invitation). 



[From the Department of Bacteriology and Immunity, Leland 

 Stanford Jr. University.] 



The typical anaphylactic reaction in smooth muscle (guinea- 

 pig uterus) is a rapid marked contraction, with little or no tendency 

 toward recovery. The muscle usually remains fully contracted 

 at the end of an ordinary experiment (30 to 60 minutes). 



The typical reaction in an immune muscle is a similar contrac- 

 tion, followed by a fairly rapid recovery. Relaxation usually 

 begins in from 2 to 3 minutes. The muscle may be fully relaxed 

 by the end of 15 minutes. 



If an immune muscle is rendered bloodless by transfusing it 

 with Locke's solution, its reaction to the foreign proteid is in- 

 creased. The muscle also loses its power of recovery (relaxation) 

 after the contraction. The transfused immune muscle, therefore, 

 reacts in the same way as a transfused anaphylactic muscle. 



From this it would appear that the fixed cellular elements are 

 identical in the two muscles, and that the differences in their 

 reaction are due to differences in the circulating substances they 

 contain. 



107 (1039) 



Relation of dosage to reaction in anaphylactic shock. (Pre- 

 Uminary communication.) 



By Marcus C. Terry and E. R. Andrews (by invitation.) 



[From the Department of Bacteriology and Immunity, Leland 

 Stanford Jr. University.} 



In support of the anaphylatoxic theory of anaphylaxis it has 

 been pointed out that to produce a fatal dose of anaphylatoxin 

 in vitro certain quantitative relations must be maintained between 

 the foreign and the anaphylactic serum. An excess of the foreign 

 protein results in the production of a non-fatal dose of the toxin. 



