198 



Scientific Proceedings (68). 



119 (1051) 



Metabolism in the dog before and after splenectomy. 



By Samuel Goldschmidt, Ph.D. and R. M. Pearce, M.D. 



[From the John Herr Musser Department of Research Medicine, 

 University of Pennsylvania.] 



Summary. 



Four dogs in nitrogen equilibrium were studied as to total 

 output of nitrogen in urine and feces, output of ammonia, creatin 

 and creatinin in the urine, and iron and fat in the feces. In each 

 a preliminary control period of seven days was followed by like 

 periods at intervals after splenectomy varying from three days to 

 three months. 



In three of the four animals the removal of the spleen caused 

 no change in nitrogen metabolism, fat utilization or iron elimina- 

 tion. Two of these animals showed no change in the blood picture 

 and the third only a slight non-progressive anemia. A fourth 

 animal which developed eventually a moderately severe anemia 

 showed slight loss of weight, a disturbance of nitrogen balance 

 and of creatin-creatinin partition and an increased elimination 

 of iron. 



The following conclusions are reached: (1) that the removal 

 of the normal spleen in an animal which remains otherwise normal 

 causes no disturbance of metabolism: (2) that when disturbances 

 of metabolism occur they are in all probability to be explained by 

 the anemia which frequently follows splenectomy and not by a 

 disturbance of metabolism consequent upon the absence of the 

 spleen. 



120 (1052) 



Coagulation in relation to the proteid constituents of the blood. 

 By Alfred F. Hess and E. J. Banzhaf. 



[From the Board of Health Laboratories , New York City.] 



As is well known there is a rearrangement of the proteins of 

 the blood in the course of immunization. The most notable 



