2 l6 



Scientific Proceedings (68). 



Atropin, either locally or intravenously, also inhibited the peris- 

 talsis, as had been shown by Harnack. 



The same effects were also obtained with the nitrites and with 

 atropin when increased peristalsis was brought on by the local 

 effect of heat, secured by placing warm water in the crystallizing 

 dish window. The increased peristalsis resulting from this pro- 

 cedure was inhibited by amylnitrite, nitroglycerine and sodium 

 nitrite, and atropin, exactly as was the lead peristalsis. Similar 

 effects were obtained when the peristalsis was produced by direct 

 faradization of the solar plexus which also was inhibited by these 

 drugs. 



These experiments establish the role of the nitrites as inhibitors 

 of intestinal peristalsis, and furnish an experimental basis for the 

 therapeutic results obtained by Riegel and Pal in lead colic, and 

 by the latter also in the gastric crises of tabes, by the adminis- 

 tration of amylnitrite; and they demonstrate that the mechanism 

 in these cases is probably not merely the change in blood pressure 

 but particularly the inhibition of intestinal spasm. 



The results are quite uniform, sudden and striking enough to 

 warrant its use as a class exercise in experimental pharmacology. 



132 (1064) 



Observations upon a rat sarcoma treated with emulsions of 

 embryonic tissues. (Preliminary Report.) 



By Kenneth Taylor, M.A., M.D. (By invitation.) 



[From the Department of Pharmacology, University of Minnesota, 



Minneapolis.] 



In view of the accepted value of total embryo emulsion as on 

 immunizing agent against propagable tumors first demonstrated 

 by Schone (Munch. Med. Woch., 1906, LIII, 2517) and later used 

 successfully by many other investigators, the following notes on 

 the influence of special embryonic tissues and of placenta on 

 established rat sarcoma seem of sufficient interest to be reported. 



The tumor used in these experiments was a sarcoma kindly 

 supplied the laboratory by Dr. Loeb. During the period covered 

 by the investigations it showed the following biological charac- 

 teristics: 



