Duration of Life in Renal Insufficiency. 3 



palpable thrill the lumen is in danger of becoming obliterated — 

 as by the formation of a cylindrical fibrous cord beneath the band 

 — and thus cancel the experiment; and in the cervical rib cases 

 we may assume, argumentatively, that the subclavian artery, 

 compressed to the stage sufficient to produce an aneurism, is likely 

 to become totally occluded in the presumably considerable time 

 required for the manifestation of the dilatation. Thus, in dogs a 

 number of months must apparently elapse after the application 

 of the band before a dilatation in striking degree can occur. In 

 the two cases, observed just one year apart, 5 months and 20 

 days, and 6 months and 19 days, respectively, had elapsed. In 

 the second of these, however, a dilatation of less than one mm. was 

 found at the expiration of 2 months. 



2 (1066) 



A comparison of the effects of glucose and of meat administration 

 upon the non-protein blood nitrogen and the duration 

 of life in experimental renal insufficiency. 



By J. H. Austin and S. S. Leopold. 



[From the John Herr Musser Department of Research Medicine and 

 the William Pepper Clinical Laboratory.] 



The following study was undertaken to determine (1) whether 

 those dietary factors that tend to increase the non-protein blood 

 nitrogen in acute insufficiency also tend to shorten the duration 

 of life, and (2) the value of glucose in prolonging life in acute renal 

 insufficiency. The method adopted was to observe the daily 

 curve of non-protein blood nitrogen and the duration of life after 

 complete renal insufficiency had been induced by bilateral ureteral 

 ligation in a series of dogs; half the animals being given glucose, 

 the other half, meat. 



Six dogs were divided into two groups of three each. One 

 group was fed upon beef heart, the other upon glucose dissolved 

 in water. On the third day, 5 c.c. of blood was taken from the 

 jugular vein for estimation of the total non-protein nitrogen by 

 the Folin method, and immediately thereafter each dog was 

 etherized and both ureters ligated. On the following day, blood 



