4 



Scientific Proceedings (69). 



was again taken in the same manner and the diet resumed as 

 before operation. Every day thereafter blood was taken before 

 feeding. When the stomach became unretentive, the glucose 

 dogs were given ten per cent, solution of dextrose in distilled 

 water intraperitoneally. The meat dogs when they refused the 

 meat were allowed water as desired. 



At autopsy, all the ureters were found satisfactorily ligated, 

 the pelvis of the kidney was filled but not materially distended and 

 there was no evidence of infection. In the animals receiving 

 glucose solution intraperitoneally, there was no evidence grossly 

 of free fluid in the peritoneal cavity. 



The following facts were noted. After forty-eight hours on 

 the diets, but before ureteral ligation, the blood nitrogen of the 

 two groups was the same. The day after operation, neither meat 

 nor glucose having been given the day of the operation, the blood 

 nitrogen in both groups was almost the same, possibly a little 

 lower in the glucose group; the loss of weight at this time was 

 the same in the two groups. Forty-five hours after operation, 

 the meat animals having retained their feeding the day previous, 

 while the glucose animals had vomited, the loss of weight was 

 distinctly greater in the glucose group; the blood nitrogen was 

 distinctly lower in the glucose group. Sixty-nine hours after 

 operation only one of the meat group was surviving. All of the 

 glucose group were surviving, and exhibited blood nitrogens com- 

 parable with those of the meat group of twenty-four hours earlier. 

 Duration after operation was practically the same in animals 39 

 (meat) and 34 (glucose) ; the two other meat animals survived a 

 distinctly shorter time than the two other glucose animals. 



In these experiments, the condition that makes for a lower 

 blood nitrogen also appears to make for a longer duration of life 

 after acute renal insufficiency, but for confirmation of these findings 

 and for further investigation of the factors involved, additional 

 studies are in progress. 



