Blood Fat in Relation to Heat Production. 



7 



than that occupied previous to either auricular or ventricular 

 systole. In the latter portion of diastole (diastasis) they gradually 

 float upward but to a slight extent only. Superimposed upon the 

 main curves of closure are found oscillations of much smaller 

 amplitude and of shorter period. Further investigation is neces- 

 sary before it may be justly concluded that these correspond to 

 the vibrations responsible for the heart sounds. 



The conclusion is reached that the mitral valves undergo two 

 movements toward closure in each cardiac cycle, the first near 

 the end of auricular systole, which is transient and incomplete, 

 and the second lasting throughout ventricular systole which is 

 complete and insures the effective closure of the valves. 



5 (1069) 



Blood fat in relation to heat production and depth of narcosis. 



By J. R. MURLIN and J. A. RlCHE. 



[From the Physiological Laboratory of the Cornell University Medical 

 College, New York City.] 



Experiments on dogs have been designed to answer the ques- 

 tions: (1) whether fat injected directly into the circulation can 

 be oxidized at once, and (2) what is the relation between the 

 concentration of fat in the blood and the heat production. Inci- 

 dentally it has been necessary to determine whether the depth 

 of narcosis had any effect on the amount of fat in circulation, and 

 on the heat production. 



The following experiments may be cited as typical of the 

 effect on percentage of blood fat and on heat production, of a 

 single intravenous injection of 100 c.c. 3 per cent, emulsion of 

 lard oil. It will be seen that the heat production rises and the 

 R. Q. falls as the fat becomes more concentrated in the blood, 

 indicating, therefore, that the injected fat burns. 



In order to insure complete muscular rest chloretone was 

 administered to a number of the animals and it was while con- 

 trolling the effect of this narcotic that the following observations 

 were made: (1) The percentage of blood fat runs parallel with the 

 depth of narcosis, i. e., the deeper the narcosis the lower the blood 



