10 



Scientific Proceedings (69). 



Applying these principles to the total non-protein nitrogenous 

 products, it is found that in a subject of average weight, for every 

 gram of nitrogen retained, the non-protein nitrogen of the blood 

 should be increased 1.33 mg. per 100 c.c. According to these 

 calculations, in the cases presented here, if none of the retained 

 nitrogen were assimilated or stored, and all of it circulated as 

 waste-nitrogen because the kidneys did not excrete it, the figures 

 shown in the table would be obtained. 



This table shows that a positive balance of nitrogen in cases 

 of nephritis on a mixed diet is not necessarily followed by a 

 corresponding increase in the non-protein nitrogen of the blood. 

 It is evident that discretion must be exercised in interpreting a 

 normal figure for non-protein nitrogen of the blood as indicating 

 that no nitrogen retention has taken place, and in considering a 

 positive nitrogen balance as an absolute indication of the inability 

 of the kidney to excrete this substance. 



7 (1071) 



On the occurrence and distribution of potassium in normal and 

 nephropathic kidney cells. 1 



By Wm. deB. Mac Nider. 



[From the Laboratory of Pharmacology, The University of North 



Carolina.] 



The observations which are contained in this summary are 

 based on the microchemical demonstration of potassium in the 

 kidney cells of thirty-four dogs. The animals have varied in 

 age from four months to something over ten years. Four of the 

 animals may be grouped as "normal animals." They did not 

 receive any nephrotoxic substance and neither were they subjected 

 to the action of an anesthetic. After a period of three days of 

 observation these animals were killed by shooting. 



The remaining thirty animals were rendered nephropathic 

 by uranium nitrate in the dose of 4 mg. or 6.7 mg. per kilogram. 

 They were anesthetized by either Grehant's anesthetic in 60 per 

 cent, strength, or by morphine-ether. 



1 Aided by a grant from the fund for scientific research of the American Medical 

 Association. 



