12 



Scientific Proceedings (69). 



4. Such accumulations of potassium salts are as marked in the 

 kidney epithelium of nephropathic animals which are polyuric, 

 as they are in the nephropathic animals which have been rendered 

 anuric. 



5. The above observation would tend to minimize the impor- 

 tance of potassium in being responsible for a lack of function on 

 the part of the kidney. 



6. The age of the animal has apparently no constant influence 

 on the amount of potassium microchemically demonstrable. 

 However, the oldest animal of this series showed the most marked 

 potassium precipitate. In this animal, and one other of the 

 series, which were anuric from uranium, and in which the epi- 

 thelium of the convoluted tubules had undergone a severe swelling 

 and partial necrosis, not only did the cytoplasm of these cells 

 give the potassium reaction but potassium was also demonstrated 

 in the nucleus of the cell. 



8 (1072) 



The action of animal extracts upon the flow of bile. 



By Isaac Ott, M.D., and John C. Scott, M.D. 



[From the Laboratory of Experimental Research, Medico-Chirurgical 

 College of Philadelphia.] 



Our experiments were made upon etherized cats. We injected 

 secretin at intervals and determined that equal doses of secretin 

 were followed by equal increments in the bile secretion. The 

 cystic duct was previously ligated close to the common duct into 

 which a glass cannula was inserted. After determining the effect 

 of a dose of secretin, we waited some time and then injected an 

 equal dose of secretin plus the infusion of the animal extract. 

 The drops of bile were counted for five-minute periods. We 

 found that adrenalin and the hypophysin of Fiihner (pituitrin) 

 greatly slowed the secretion. Pancreas slightly diminished the 

 secretion. Thyroid extract had hardly any effect. Tonsil extract 

 caused a marked increase. Thymic extract decreased it. Para- 

 thyroid, mammary and corpus luteum had no action. 



