SCIENTIFIC PROCEEDINGS. 



Abstracts of Communications. 

 Seventieth meeting. 



New York Post-Graduate Medical School, November 17, 191 5. 

 President Lusk in the chair. 



18 (1082) 



Production of pneumonic lesions by intrabronchial insufflation of 

 unorganized substances. 



By B. S. Kline and S. J. Meltzer. 



[From the Department of Physiology and Pharmacology of the 

 Rockefeller Institute for Medical Research.] 



Earlier communications from this department have shown 

 that intrabronchial insufflations of virulent pneumococci in dogs 

 produce lobar pneumonia similar in every respect to the lesions 

 of lobar pneumonia as observed in human beings. In later experi- 

 ments, Wollstein and Meltzer demonstrated that, at least macro- 

 scopically, typical pneumonic lesions can be produced also by 

 avirulent pneumococci and by the saprophytic bacillus megather- 

 ium. Microscopically it was established that the lesions produced 

 by the virulent pneumococci contained a great amount of fibrin, 

 while the lesions produced by the last-named organisms (avirulent 

 pneumococci and bacillus megatherium) contained only very 

 little fibrin. 



In the present series of experiments various unorganized sub- 

 stances were insufflated into the bronchi of dogs which were 

 killed after twenty-four or forty-eight hours. The substances 

 were: aleuronat suspension in starch solution (autoclaved), starch 

 solution, egg yolk, lecithin, egg white and cholesterin. The 

 results were striking and are as follows: aleuronat, starch, egg 



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