30 



Scientific Proceedings (70). 



yolk and lecithin produced lesions which macroscopically could 

 not be distinguished from those produced by insufflation of 

 pneumococci. Egg white never produced pneumonic lesions of 

 any extent and even in the occasional patches many of the bron- 

 chioles and alveoli containing this protein showed microscopically 

 no nucleated cells whatever in their lumina. The few patches 

 produced by cholesterin were associated with the bronchioles and 

 adjoining alveoli. We shall not describe here the nature of the 

 histological pictures of the lesions under discussion; we shall 

 merely mention the fact that those lesions produced by aleuronat 

 and starch were similar microscopically to those produced by 

 virulent pneumococci, that is, the lesion contained in addition 

 to an exudate of similar cells, etc., a good deal of fibrin; while 

 lesions produced by egg yolk and lecithin resembled more those 

 produced by avirulent pneumococci and bacillus megatherium. 



In brief, we may say that our experiments have demonstrated 

 definitely that the hepatization of the lungs, similar to the one 

 observed macroscopically in lobar pneumonia, can be produced 

 by such unorganized substances as aleuronat, starch, egg yolk 

 and lecithin, while egg white does not produce such an effect. 

 The following chart illustrates our results: 







Lesion. 





Substance Injected Intrabronchially. 



No. of 

 Animals. 



Patches of 

 Consolida- 

 tion. 



Lobar Type 

 of Consoli- 

 dation. 



Lung 

 Culture. 





8 





+ 



8 sterile. 





2 



+ 





2 





7 





+ 



6 sterile. 





11 





+ 



v ;'d?). 





1 



+ 









6 





+ 



4 " 





5 







s " 





4 



+ 





4 " 



