Anaphylatoxin. 



37 



period. They lost an average of four pounds. They increased 

 this average loss during the next two months and ten days to 

 six pounds. There was no noticeable alteration in the pulmonary 

 conditions. 



All the cases took three pints of milk a day. The special 

 cases, one quart of "reactor" milk and one pint of pasteurized 

 milk. The controls, three pints of pasteurized milk. 



The "reactor" milk contained less butter fat than the pas- 

 teurized milk. The use of this raw "reactor" milk, judging by 

 its action upon two cases of adult pulmonary tuberculosis, is 

 probably contraindicated in dysentery and hemorrhage. This 

 dysentery case proved fatal. It was used in one far advanced 

 case of adult pulmonary tuberculosis and apparently agreed ith 

 her, although her weight remained unchanged. 



We mixed diphtheria antitoxine with milk for the purpose of 

 determining by analogy if the tuberculous antibodies when present 

 in milk, would be destroyed by pasteurization. These mixtures 

 after having been heated were tested with toxin, in order to 

 determine whether any destruction of antibody had taken place. 

 We found that the antitoxine was not materially affected by 

 heating at 6o° C. for 20 minutes. Certain milks we have tested 

 showed the presence of some natural substance or antibody which 

 neutralized diphtheria toxine. I wish to thank Mr. E. J. Banzhaf 

 for his aid in making these antitoxine tests. 



23 (1087) 



Anaphylatoxin and the mechanism of anaphylaxis. 



By Richard Weil. 



[From the Department of Experimental Medicine of Cornell University 



Medical College.] 



Precipitin is identical with the antibody effective in passive 

 sensitization. This is demonstrated by injecting a guinea-pig 

 with the precipitate formed by a mixture of horse serum with 

 the serum of a rabbit immunized thereto. This guinea-pig, if 

 tested after an interval of three days by the intravenous injection 

 of horse serum, presents a violent, at times a fatal anaphylactic 

 response. 



