Diabetes Mellitus and Splenohepatomegaly. 39 



c.c. Serum heated at 56 0 in amounts of 0.2 c.c. The same 

 results were obtained when horse serum and the serum of a rabbit 

 immunized thereto were used as antigen and antibody. 



Hence we may conclude that complement plays no role in the 

 anaphylactic reaction. Inasmuch as complement is essential to 

 the production of anaphylatoxin, this is equivalent to saying that 

 anaphylatoxin plays no role in anaphylaxis. 



24 (1088) 



The isolation of a toxic substance from the blood of uremic 



patients. 



By Nellis B. Foster, M.D. 



[From the Department of Medicine, Cornell Medical College and the 

 New York Hospital.} 



The analyses of bloods from cases of uremia have yielded a 

 substance which is toxic. Control analyses of bloods from a 

 wide variety of conditions not associated with uremia failed to 

 discover a similar substance. Guinea-pigs were used as the test 

 animal and enough material can be recovered from 200 c.c. of 

 uremic blood to cause death. The isolation of the substance was 

 effected by a combination of several methods in current use for 

 the separation of animal bases. 



25 (1089) 



The possible association of diabetes mellitus and splenohepato- 

 megaly, Goucher; report of a case. 



By J. R. Williams and M. Dresbach. 



[From the Department of Physiology, Cornell Medical College, 

 Ithaca, N. Y.] 



The following case, which we have recently had under observa- 

 tion, is of clinical and scientific interest because of the evidence 

 it presents of the coexistence of diabetes mellitus and spleno- 

 hepatomegaly, Goucher. 



The history, in brief, is as follows: Patient, male, single; 



