62 



Scientific Proceedings (71). 



present in a few large cells, probably of endothelial type, in the 

 scars, but the lesions seen in rabbits were not obtained. There 

 was also some fat in the glomerular tufts. The latter observation 

 might be considered as evidence that uranium produces a vascular 

 lesion and that such a preexisting lesion facilitates the absorption 

 of anisotropic fat as argued by Knack. The deposit of fat in the 

 aortas of these animals however was not increased. 



36 (1100) 



Lesions produced in rabbits by repeated intravenous injections 

 of living colon bacilli. 



By C. H. Bailey, M.D. (by invitation). 



[From the Pathological Laboratory of Stanford University Medical 



School.] 



Of a series of rabbits injected intravenously with a strain of 

 colon bacillus every 3 or 4 days over considerable periods, the 7 

 animals which withstood this treatment longest, namely 88, 98, 

 102, 113, 115, 116, and 142 days, showed pronounced lesions in 

 the kidneys, spleen, and liver. In the kidneys there is produced 

 a hyaline and fibrous thickening of the vascular loops of the glo- 

 meruli with the formation of hyaline bodies in the tufts and 

 occasional adhesions between the tufts and glomerular capsules. 

 The tubular epithelium shows more or less degeneration and many 

 casts are present in the tubules. The interstitial connective 

 tissue shows a beginning cellular thickening, apparently not due 

 to the spontaneous nephritis frequently seen in rabbits. 



The livers show in certain cases central necroses with hyaline 

 degeneration of the liver cells about these areas and elsewhere. 

 In two cases there is deposited between the rows of liver cells in 

 the middle and peripheral portions of the lobules a homogeneous 

 amyloid-like substance. The livers in all cases show a more or 

 less marked cellular increase of the periportal connective tissue — 

 the latter possibly a spontaneous lesion. 



The spleens show a fibrous thickening of the reticulum of the 

 pulp with some hyaline formation. The most striking lesion is a 

 formation of connective tissue with much amyloid-like material 

 about the peripheries of the Malphigian bodies, in cases almost 

 replacing these structures. 



