70 



Scientific Proceedings (72). 



measured and its sugar content estimated. Specific gravity was 

 determined with a 10 c.c. pycnometer; hemoglobin with the Sahli 

 instrument; blood sugar and urine sugar by the Lewis-Benedict 

 and Benedict methods, respectively. 



I. Fisher and Wishart have presented evidence that (con- 

 trary to Starling's hypothesis) after the ingestion of 50 gm. of dex- 

 trose by a dog, there is a diminished formation of urine in spite of 

 a dilution of the blood, as indicated by hemoglobin determinations. 



Similar results were obtained also in the present series of 

 experiments after intravenous injections, estimations of the specific 

 gravity as well as the hemoglobin content of the blood being made. 

 The following experiments indicate clearly that simple increase 

 or decrease in the concentration of the blood following injection 

 of crystalloids does not necessarily result in a corresponding in- 

 crease or decrease in urine formation, and that there may be a 

 definite diuresis without any material change in the concentration 

 of the blood. 



Exper. 



Injected. 



Change in Sp. Gr. 

 in 30 Min. 



Urine in 

 30 Min. 



Rate per 

 Hour. 



May 14, 7 K. . . . 

 May 24, 9 K. . . . 

 May 27, 8 K. . . . 



40 gm. dextrose, 10 min. 

 30 c.c. water, 30 min. 

 13 gm. dextrose, 30 min. 



I.0570 1 to 1,0592 

 1,0555 to 1,0551 

 1,0660 to 1,0631 



14 c.c. 

 9 c.c. 

 3.25 c.c. 



28 C.C. 

 18 C.C. 

 6.5 C. C. 



II. Complete results of the experiments would be too bulky 

 for publication, but the following summary will show the relation 

 of blood sugar, blood concentration and diuresis. The weights 

 of the animals are indicated along with the dates of the experi- 

 ments; the figures for the blood sugar represent the highest points 

 reached during the chosen periods; the maximum changes in the 

 specific gravity of the blood during the period are indicated, and 

 the urine formation is expressed in c.c. per hour. 



Exper. 



Injection. 



Blood 

 Sugar. 



Sp. Gr. 

 Decreased. 



Urine Rate 

 per Hr. 





40 gm. in 1 hr. 



•57 



1,0620 to 1,0580 



33 c.c. 





20 gm. in Yi hr. 



•55 



1,0630 to 1,0610 



50 C.C. 



May 21, 10 K 



20 gm. in 1 hr. 



.28 



1,0627 to 1,0607 



10.5 C.C. 



June 4, 9 K 



13 gm. in Yi hr. 



•50 



1,0573 to 1,0550 



12 c.c. 



June 5, 9 K 



13 gm. in 5 min. 



.68 



1,0570 to 1,0546 



55 c.c. 



May 27, 8 K 



13 gm. in Yi hr. 



•57 



r,o66o to 1,0632 



7 c.c. 



May 28, 8 K 



13 gm. in 5 min. 



.6 



1,0657 to 1,0610 



64 c.c. 



1 This change occurred 30 minutes after the injection, being preceded by a 

 marked fall (as in Starling's experiment). 



