106 Scientific Proceedings (74). 



slight ecchymoses as before. Two months after the citrate injec- 

 tions he had another one of his attacks of severe hemorrhage. 



Conclusions 



I. In hemophilia the intravenous injection of sodium citrate 

 produces an immediate and great shortening of coagulation time 

 which is followed, twenty-four to forty-eight hours later, by a 

 return of coagulation time to its former prolonged period, or by a 

 much greater prolongation of coagulation time than before. 



II. The intramuscular injection of sodium citrate seems to 

 have practically no immediate effect on coagulation time. 



60 (1124) 



The influence of intravenous injections of magnesium sulphate 

 upon the activities of the center of deglutition. 



By J. Auer and S. J. Meltzer. 



[From the Department of Physiology and Pharmacology of the 

 Rockefeller Institute for Medical Research.] 



In order to understand our experimental results the following 

 physiological facts have to be recalled. Three different phe- 

 nomena which are under the reflex control of the center of deglu- 

 tition must be distinguished: (1) The transmission of food from 

 the mouth through the pharynx into the esophagus. This is a 

 complex process which comprises the execution, in a coordinate 

 and stable manner, of three separate activities: the closure of the 

 entrances into the post-nasal cavity and into the larynx, and the 

 rapid transportation of the contents of the mouth into the proper 

 direction. We shall designate the entire action as the initial act 

 of deglutition. The reflex mechanism which controls it, is more 

 resistant to anesthesia than the two reflex mechanisms of the 

 phenomena to be mentioned next. (2) The peristaltic move- 

 ments of the esophagus. This is dependent only upon the occur- 

 rence of the first mentioned mechanism, the initial act of the 

 deglutition, and is independent of the actual passing of some con- 

 tents through the esophagus or of the anatomical continuity of the 

 latter. Transection of the esophagus or complete removal of a 



