U4 



Scientific Proceedings (74). 



1. Will creatine appear in the urine, even in the presence of an 

 abundant carbohydrate supply, if acidosis is induced? 



2. Will the elimination of creatine disappear if the acidosis is 

 abolished, quite independently of the factor of carbohydrate 

 supply? 



Upon a diet of oats and corn, containing an adequate supply 

 of carbohydrate, creatine promptly appears in the urine of the 

 rabbit. A marked condition of acidosis, as measured by the hy- 

 drogen ion concentration of the urine, is always associated with 

 this phenomenon. Oats and corn are pronounced acid-producing 

 foods. On the other hand, if a base-producing food, such as 

 carrots, is fed to rabbits with creatinuria this symptom rapidly 

 disappears as the urine becomes strongly alkaline. 



The protein per se is without special significance in the phe- 

 nomenon under discussion; for upon a diet consisting of oats, corn 

 and carrots creatine fails to appear in the urine, and the reaction 

 of the latter remains alkaline. Equally significant is the further 

 fact that the ingestion of HC1 in addition to the mixed diet causes 

 the appearance in the urine of significant quantities of creatine. 

 Simultaneously the hydrogen ion concentration of the urine is 

 markedly increased. 



The conclusion seems inevitable that there is an inter-relation- 

 ship between acidosis and creatine elimination. Creatine ex- 

 cretion may prove to be an index of a condition of acidosis in the 

 organism. 



64 (1128) 



On the production of soap jellies, and the physical conditions under 

 which jelly formation takes place. 

 (Preliminary communication.) 



By G. H. A. Clowes. 



[From the Biological-Chemical Laboratory of the State Institute for 

 the Study of Malignant Disease, Buffalo, N. Y.] 



In the course of experiments regarding the influence exerted by 

 various electrolytes on the equilibrium of emulsions, published in 

 the year 1913, the writer noted that NaCl, when used at a concen- 

 tration in excess of .4M, caused a precipitation of some constituent 



