126 



Scientific Proceedings (75). 



refined serum containing only Y2 to 1 per cent, proteid, that is to 

 say, one tenth to one fifth the quantity present in normal serum, 

 but possessing an equal potency as regards coagulation. This 

 preparation may be passed through a Berkefeld filter so as to be 

 rendered sterile. 



This euglobulin would seem to be of value for subcutaneous or 

 intravenous use in hemorrhage, particularly on account of its 

 small quantity of proteid. 



70 (1134) 



Comparative distribution of urea, creatinine, creatine, uric acid, 

 and sugar in blood and spinal fluid. 



By M. S. Fine and V. C. Myers. 



[From the Laboratory of Pathological Chemistry, New York Post- 

 Graduate Medical School and Hospital.] 



Comparative analyses of blood and spinal fluid were carried 

 out in 15 cases. These patients were suffering from nephritis of 

 various stages of severity, and gave chemical blood pictures varying 

 from practically normal to the excessive retention of uremia. 

 The concentration of urea in the spinal fluid averaged 88 per cent, 

 of that in the blood ; the concentration of creatinine, 46 per cent. ; 

 of creatine, 22 per cent.; and of uric acid, 5 per cent, of the re- 

 spective concentrations in the blood. If these differences in con- 

 centrations may be regarded as representing the relative perme- 

 ability of the cells separating the blood and spinal fluid, one notes 

 that the extent of passage into the spinal fluid is greatest for urea, 

 less for creatinine, still less for creatine and least for uric acid. It 

 is of interest to note that this represents also the order of their 

 solubility in water, and, in part, the relative ease with which 

 these substances appear to be eliminated by the kidney. 



It may be further observed that the sugar concentrations of 

 the spinal fluid in these fifteen cases averaged 57 per cent, as much 

 as that of the blood. 



