130 



Scientific Proceedings (75). 



We have much experimental evidence indicating that the unknown 

 A is principally confined to the germ of the seed. Sunflower seed 

 appears to be fairly rich in this substance. 



We have also found that the leaves of certain plants, especially 

 alfalfa and cabbage are very rich in the fat-soluble A as compared 

 with the grains. It is probable therefore that it is universally 

 associated with metabolizing plant cells. We have rats in our 

 colony which have grown to very near the normal adult size at 

 slightly below the normal rate on a simple mixture of polished rice 

 sixty and powdered alfalfa leaves forty per cent. They are in an 

 excellent condition after eight months on this diet and one female 

 has produced young. 



We wish to call attention to the importance of having found a 

 good source of the fat-soluble A in foodstuffs containing but little 

 fats and other substances soluble in lipoid solvents. We shall 

 report later on methods of isolating this substance from such 

 sources. 



73 ("37) 



The effect of exercise on the blood sugar of depancreatized dogs. 



By George M. Mackenzie (by invitation.) 



[From the Department of Pathology of the College of Physicians and 

 Surgeons, Columbia University, New York.] 



Blood sugar curves of dogs made to run on the treadmill one to 

 four days after extirpation of the pancreas showed: 



1. That after 20 to 30 minutes of such exercise, in animals 

 which were being fed 200 grams of meat and bread daily, there 

 occurred a fall in the amount of reducing substance in the blood, 

 sometimes amounting to as much as 100 mgm. per 100 c.c. 



2. That in starved animals such exercise caused a rise in the 

 amount of reducing substance in the blood, amounting in one case 

 to 85 mgm. per 100 c.c. during 30 minutes of exercise. 



The conclusions suggested by these results are that, even after 

 complete extirpation of the pancreas the power of sugar consump- 

 tion is not entirely lost, and that there may be a difference in the 

 power of such animals to utilize sugar according as it is derived 

 from tissue proteins or by absorption from the intestinal tract. 



