142 



Scientific Proceedings (75). 



The results confirmed our earlier work. The temperature rose 

 steadily after injection, the height being roughly proportional to 

 the dose given. The maximum was attained in from three to 

 five hours, after which the temperature gradually returned to 

 normal. As an example, a rabbit weighing 2,500 grams was 

 injected subcutaneously with 25 c.c. sterile sodium chloride 

 solution, m/6. In five hours a maximum temperature of 40.4 0 C. 

 was recorded. The next day 35 c.c. were injected, with a maxi- 

 mum of 41 0 C. in five hours. The following day 20 c.c. gave a 

 maximum of 40 0 C. in three hours. 25 c.c. Ringer's solution caused 

 a slight rise, but not so marked as the pure sodium chloride (39. 8° 

 as against 40.4 0 ). This is not in accord with our original findings, 

 and it is possible that the distilled water used at that time was not 

 perfectly pure. Our present results are more in harmony with 

 Loeb's theory of balanced solutions, and with the results of other 

 workers. 



As intravenous injections become more and more general, it 

 would seem wise, when sodium chloride is used as a menstruum 

 for other substances, that the amount injected should be so gradu- 

 ated as to fall below that which will cause a febrile reaction; or 

 better still, Ringer's solution should be used. 



79 (1143) 



The influence of morphin upon the elimination of intravenously 



injected dextrose. 



By I. S. Kleiner and S. J. Meltzer. 



[From the Department of Physiology and Pharmacology of the Rocke- 

 feller Institute for Medical Research]. 



In a series of eight experiments dextrose was injected into 

 dogs which had received 10 mg. of morphin per kilo of body 

 weight. Ten other dogs received similar dextrose injections but 

 no morphin, the slight operation having been performed under 

 local anesthesia produced by cocain or ethylchloride. The dosage 

 of dextrose was 4 gm. per kilo of body weight, injected in a 20 

 per cent, solution in about one hour. The difference in the urinary 



