Influence of Morphine upon Injected Dextrose. 143 



and blood findings in these two series of experiments was quite 

 striking. In the eight morphinized animals the average quantity 

 of sugar in the urine secreted in two hours and a half (that is, 

 from the beginning until one and a half hours after the end of the 

 injection) amounted to 63 per cent, of the injected sugar, 80 

 per cent, being the largest and 50 per cent, the smallest quan- 

 tity. The average quantity of sugar in the urine of six non- 

 morphinized dogs in two hours and a half, amounted only to about 

 17 per cent, of the injected sugar, 30 per cent, being the highest 

 and 4 per cent, the lowest quantity. There was, also, however, 

 a difference between the two series of dogs in the volume of urine 

 secreted. In the morphinized dogs the average amount of the 

 injected sugar solution was 137 c.c. and of the urine 197 c.c. ; in 

 the non-morphinized dogs the average of the injected sugar solu- 

 tion was 187 c.c. and of the urine only 83 c.c. On this account 

 experiments were made on four non-morphinized dogs in which 

 the dextrose was dissolved in M solution of sodium sulphate, 

 and there resulted a reversal in the relation of the volumes of the 

 injected sugar and the urine: 212 c.c. of dextrose solution injected 

 and 281 c.c. of urine secreted. Nevertheless, the elimination of 

 sugar in the urine was not increased. In fact, in these four 

 experiments the elimination of sugar in the urine was even less; 

 it amounted on the average only to about 9 per cent, of the in- 

 jected sugar, 13 per cent, being the highest and 7 per cent, the 

 lowest quantity. 



As to the sugar content of the blood, we may state briefly that 

 in the non-morphinized dogs the original level was reached in half 

 an hour after the end of the injection, while in the morphinized 

 dogs that level was reached only one hour and a half after the 

 end of the injection. 



Summarizing briefly our results with regard to the effect of 

 morphin we may say that, on the one hand, it increases consider- 

 ably the elimination through the kidneys of intravenously injected 

 dextrose, while, on the other hand, it perceptibly retards the re- 

 turn of the sugar content of the blood to its previous level. 



