150 



Scientific Proceedings (76). 



reaction stage. At this time the embryos when first stimulated 

 almost always give a reaction toward the side stimulated and 

 only exhibit the avoiding reaction after several responses of the 

 more primitive type. This would seem to indicate that connec- 

 tions across the body occur only as a summation of stimuli. 



In conclusion, it may be stated that the early tactile responses 

 in the frog embryo are very similar to those of Amblystoma ex- 

 cept that they are preceded by a constant response toward the 

 side stimulated. The localization of the decussation in the cord 

 seems to cover a wider region than that described by Coghill for 

 the salamander and in this region to appear simultaneously over 

 a length of one half to one millimeter. 



84 (1 148) 



Permeability vs. tolerance of the kidneys for sugar in diabetes 



mellitus. 



By Albert A. Epstein. 



[From the Department of Physiological Chemistry, Mt. Sinai 



Hospital.] 



In the study of the relation of hyperglycemia to glycosuria in 

 diabetic and non-diabetic conditions, the following facts have 

 been elicited: 



1. In diabetic individuals possessing healthy kidneys the 

 glycosuria bears a definite relationship to the hyperglycemia. 1 



2. Cases of diabetes with definite renal disease, frequently 

 show no relationship between the hyperglycemia and the gly- 

 cosuria. 2 The hyperglycemia in such individuals is usually 

 greater in proportion to the glycosuria than it is in those with 

 normal kidneys. Means which promote renal secretion, increase 

 the urinary output of sugar, with a consequent reduction of the 

 hyperglycemia. 



3. Acute impairment of renal function in clinical and experi- 



1 Epstein, Albert A., "Studies on Hyperglycemia in Relation to Glycosuria," 

 Monograph, 1916, New York. Proc. Soc. Exper. Biol, and Med., Vol. XIII, 

 p. 67, 1916. 



s Id. 



