154 



Scientific Proceedings (76). 



cretion in cubic centimeters per minute were also determined in 

 each specimen. 



In an apparently normal subject the whole blood contained 

 0.12 per cent, glucose, the percentage in the plasma being slightly 

 lower, and that in the unwashed corpuscles, slightly above that 

 in the whole blood. The sugar in the urine was apparently about 

 the same as in the plasma. 1 Following the ingestion of 75 grams 

 glucose in 400 c.c. fluid the sugar in the blood rose evenly and 

 rapidly, reaching its highest point in about 1 hour, returning to 

 normal by the end of 2^ hours, falling below normal at the third 

 hour, and from the fourth to the sixth hour retaining its normal 

 level. The increase and decrease in the plasma seemed to be a 

 little more rapid than in the whole blood, although the difference 

 was very slight. The hemoglobin dropped 3 to 5 per cent, in 

 from 15 to 70 minutes, then increased rapidly, later more slowly, 

 reaching its normal in from 1^ to 3 hours. Urinary secretion 

 decreased during the development of the hyperglycemia, increas- 

 ing as the blood sugar decreased. The sugar in the urine apparent- 

 ly increased at the same rate as in the blood up to a concentration 

 of 0.17 per cent. From this point the increase was much more 

 rapid in the urine, so that when the blood sugar had reached its 

 highest point, 0.23 per cent, at the end of one hour, the urine 

 contained 0.9 per cent, sugar. The decrease in the urine sugar 

 was rapid for the succeeding hour, then much slower, so that the 

 normal concentration was not reached until about 6 hours after 

 the ingestion of the sugar. 



In a case of renal diabetes there was an initial hypoglycemia 

 with a marked glycosuria (3 per cent.). The blood sugar curve 

 was of the normal type, but the urine sugar curve abnormally high. 



In a case of early diabetes the initial blood sugar and urine 

 sugar values were normal. Alimentary hyperglycemia was rapid, 

 the highest point being reached in about one-half hour, return to 

 normal taking place in less than 2 hours. The urine sugar curve 

 was abnormally high with a sluggish return to normal. 



In diabetes of long standing without signs of nephritis, the 

 initial blood sugar value was high (0.2 per cent.), the urine value 

 normal. Blood sugar and urine sugar curves were of the previous 



1 See Myers, V. C, Proc. Soc. Exper. Biol, and Med., 1916, XIII, 180. 



