Scientific Proceedings (76). 



sidering all the facts we may conclude that while proliferation 

 in the first phase depends upon the absence of the corpus luteum 

 and upon the activity of another constituent of the ovaries, the 

 proliferation which is found following the first period is in all 

 probability due to substances secreted by the corpus luteum. 1 

 In the guinea pig, however, the effect of this substance becomes 

 apparent only at a much later period than in the rabbit. The 

 adaptive character of this phenomenon is clear if we remember 

 that in the rabbit the functioning of the mammary gland is re- 

 quired at a much earlier period than in the guinea pig. Repeated 

 intraperitoneal injections of corpus luteum of the cow does not 

 produce a proliferation of the mammary gland in the guinea pig. 



92 (1156) 



The chlorides of the plasma in uremia. 

 By Franklin C. McLean. (By invitation.) 



[From the Hospital of the Rockefeller Institute for Medical Research, 



New York.] 



Previous investigations relating to the chlorid content of the 

 blood or plasma in uremia have yielded conflicting results, some 

 figures much lower than the lowest normal limit having been 

 reported. 2 It is known that the chlorid content of nephritic 

 plasma is usually somewhat higher than that of the average nor- 

 mal plasma, but the findings in uremia have apparently so far not 

 been explained. 



We have been able, in several cases, to make frequent obser- 

 vations of the chlorid content of the plasma of nephritic individuals 

 during life, and up to the time of death in uremic coma. We have 

 found a diminution of chlorids in the plasma to be the usual ac- 

 companiment of uremia, and we have found this decrease of 

 chlorids in the plasma to accompany the increased H + ion con- 

 centration frequently observed in the blood of uremic patients 

 shortly before death. 



1 The latter part of this conclusion depends in part at least upon the correctness 

 ot the observations of Bouin and Ancel and Frank and Unger. 



2 Strauss, H., "Die chronischen thieren entziindungen," Berlin, 1902, 51. 



