Autolysis of Anaphylactic and Immune Tissues. 177 





Total N per Gram. 



Percentage of Non-coagailable N. 



Post Mor- 

 tem Autoly- 

 sis. 



Imme- 

 diate. 



6 Hrs. 



24 Hrs. 



3 Days. 



Normal 



0.034 gr. 

 0.032 gr. 

 0.029 gr- 

 .022-.026 gr. 



10.5 



13- 5 



14- 5 

 16-18 



13-5 

 16 

 16.5 

 18-20 



20 

 21.5 

 22 

 25-30 



23 

 26 

 30.5 

 40-45 



12.5% 

 12.5% 

 16 % 

 26 % 



Anaphylactic. . . 



Selected cases . . 



The table shows a slight decrease in the average total N per 

 gram of liver tissue in the anaphylactic animals, and a distinct 

 decrease in the immune animals, the decrease being particularly 

 marked in certain selected cases. 



The table also shows a distinct increase in the average per- 

 centage of non-coagulable N in both anaphylactic and immune 

 animals, confirming data recently published by Pick and Hashi- 

 moto. 1 



Contrary to their findings, however, the anaphylactic livers 

 showed no increase in the amount of post-mortem autolysis. 



A distinct increase in post-mortem autolysis, however, was 

 observed in the immune livers, the phenomenon being particularly 

 marked in certain selected cases. The selected animals were for 

 the most part guinea pigs in which a marked Arthus phenomenon 

 had been produced. 



100 (1164) 



Hepatic bacteriolysins. (Preliminary report.) 



By W. H. Manwaring and Harry C. Coe. 



[From the Department of Bacteriology and Immunity, Leland Stan- 

 ford, Jr., University.] 



If pneumococci are deposited by perfusion methods in the 

 liver of a normal rabbit, in the presence of normal rabbit blood, 

 and the infected organ is now incubated at 37 0 C, a slight multi- 

 plication of the deposited pneumococci takes place. After 5 or 6 

 hours, the tissues begin to be distinctly overgrown by the mic- 

 roorganisms. 



1 Pick and Hashimoto, Arch. f. exper. Path. it. Pharm., 76, 1914, p. 89; Zeit. f. 

 Immunittltsf., 21, 1914, p. 237. Compare also Barger and Dale, Biochem. Jour., 8, 

 1914, p. 670. 



