Exhaustion of the Epinephrin Store. 185 



supply is intact, as compared with the other adrenal whose splanch- 

 nic supply has been previously severed. We can confirm his 

 statement as to the difference in the content produced under the 

 influence of morphin but we do not think that fright has anything 

 to do with the result since it is also obtained in dogs where there 

 are no signs of fright. 



2. The signs of morphin-" fright" can all be elicited by ad- 

 ministering morphin to a cat in which one adrenal has been re- 

 moved and the splanchnic supply of the other cut and in which 

 accordingly no demonstrable liberation of epinephrin through the 

 splanchnics takes place. A cat in this condition behaves identi- 

 cally in the same way as a cat whose adrenal splanchnic supply 

 has been cut on one side but left intact on the other. The pupils 

 are widely dilated and there is the same characteristic restlessness 

 and incessant movement. The content of epinephrin in the re- 

 maining adrenal of the first cat is found to be practically the same 

 as that of the adrenal removed before the administration of mor- 

 phin while the content of the adrenal with intact splanchnic 

 supply in the second cat is definitely diminished. 



3. When a cat with the splanchnic supply of one adrenal cut is 

 frightened for many hours by a dog in which also the splanchnic 

 supply of the adrenal has been divided on one side both animals 

 undoubtedly experience emotions of great intensity. Neverthe- 

 less the content of epinephrin in the gland whose nerve supply is 

 intact is not sensibly diminished as compared with the other. 



4. We can confirm the statement that /3-tetrahydronaphthy- 

 lamine causes in cats extreme exhaustion of the epinephrin store 

 of an adrenal whose nerve supply is intact as compared with its 

 fellow whose nerve supply has been previously severed. 1 Elliott 

 associates this with the emotional "alarm." We have attempted 

 to test this interpretation by making observations on rabbits. 2 



1 Elliott, loc. cit. 



2 Division of the nerves to one adrenal is complicated in the rabbit by the fact 

 that the right adrenal seems to derive a portion of the nerve supply concerned in 

 changes in the epinephrin store from the left splanchnic (Kahn, Archiv fiir die 

 gesammte Physiologic, 1911, CXL, 209; Nishi, Archiv fiir Exper. Path. u. Pharmakol., 

 1909, LXI, 401). We therefore tried to eliminate the nervous connections of the 

 left adrenal by dividing all branches going to it from the celiac ganglion and in 

 addition cutting any strands from the lumbar sympathetic and the sympathetic 

 itself below the diaphragm. 



