Scientific Proceedings (76). 



We have not seen nearly as great a degree of exhaustion in this 

 animal as in the cat. This might be interpreted as in favor of 

 Elliott's view, since signs of "emotional" disturbance are also less 

 marked in the rabbit, although great dilatation of the pupil, in- 

 creased respiration and other symptoms are present, which, ac- 

 cording to Mutch and Pembrey 1 "give the impression that the 

 drug produces a state of increased psychic activity accompanied 

 by muscular action appropriate to the emotions." It seems to 

 us, however, more natural, considering our results with morphin 

 and "frightening" without drugs to interpret the greater effect on 

 the epinephrin content in the cat as due to some other action of 

 the drug than the hypothetical emotional disturbance. 



We determined the epinephrin content by the colorimetric 

 method of Folin, Cannon and Denis, which we found to agree 

 sufficiently well with blood pressure observations on the pithed cat. 



107 (1171) 



The liberation of epinephrin from the adrenals. 



By G. N. Stewart and J. M. Rogoff. 



[From the H. K. Cushing Laboratory of Experimental Medicine, 

 Western Reserve University.] 



The solution of the question of the liberation of epinephrin 

 into the adrenal veins and the estimation of the amount so liber- 

 ated in the absence of artificial stimulation of the splanchnics are 

 complicated by the fact that after withdrawal of blood pressor 

 substances are quickly developed in it, which give the same effect 

 as epinephrin on such objects as the vessels of a frog's legs. 2 It is 

 therefore desirable to demonstrate the fact of its liberation and to 

 assay its amount without the necessity of withdrawing blood. 

 We have done this (in the cat) by means of the denervated eye 

 reactions (of Meltzer), 3 and by the effect on the blood pressure 

 curve. 



1 J. of Physiology, 1911, 43, p. 109. 



2 Cf. Trendelenburg, Archiv f. Exper. Path. u. Pharmakol., 1915, 79, p. 154. 



* Experiments on the liberation of epinephrin by stimulation of the splanchnics, 

 in which the eye reactions were used, have been described by us elsewhere, Journal 

 of Pharmacology and Experimental Therapeutics, 1916, 8, p. 205. 



