12 



Scientific Proceedings (85). 



little value, unless the relative volumes of plasma and corpuscles 

 are known. It appears probable that the wide variations in the 

 calcium content of whole blood in apparently normal individuals 

 and variations for sex as reported by Lyman 1 may represent 

 variations in corpuscular volume rather than in the calcium 

 content of the plasma in these conditions. 



Abstracts of the Communications, 

 Pacific Coast Branch. 



Eighteenth meeting. 



San Francisco, California, October 3, IQ17. 



114 (1292) 

 Circulatory effects of tyramin. 

 By A. W. Hewlett. 



[From the Division of Medicine, Leland Stanford Jr. University.] 



The subcutaneous injection of 0.06 to 0.08 gm. tyramin into 

 normal individuals usually produces the following circulatory 

 changes: 



1. The systolic blood pressure increases markedly. 



2. The diastolic blood pressure increases to a much less extent. 



3. The pulse pressure is therefore increased. 



4. The volume pulse in the arm becomes larger. 



5. The heart rate is usually slowed. 



6. The T wave in the electrocardiogram becomes notably 

 larger with no constant change in the other waves. This alteration 

 is most constant and is usually most marked in Lead II. 



The changes in blood pressure and in the volume pulse in the 

 arm indicate that the systolic output from the heart is increased. 

 The changes in the electrocardiogram suggest those described by 

 Rothberger and Winterberg after stimulating the right stellate 

 (accelerator) ganglion. 



Where epinephrin produces marked circulatory effects after 

 subcutaneous injection these appear to be of a similar nature to 



1 Lyman, H., Jour. Biol. Chem., 1917, XXX, 1. 



