Absorptive Power of Bladder and Urethra. 45 



of serum injected intraspinally. Instead of 3.0 c.c. of normal 

 horse serum, Rosenow's serum, or immune monkey serum, 2.5 

 c.c. were used. The results were identical with those obtained in 

 Experiment I. 



The results of these two experiments unequivocally demon- 

 strate that Rosenow's serum is devoid of protective power against 

 poliomyelitic virus, while serum from paralyzed monkeys possesses 

 perfect protective power, as has been shown previously by Flexner 

 and Amoss. 



There is a further corollary to this general deduction. Once 

 it is established that the antibodies yielded by streptococci differ 

 essentially from those induced by poliomyelitic virus, the con- 

 tention that poliomyelitic virus and streptococci are identical 

 becomes untenable. 



134 (1312) 



On the comparative absorptive power for drugs of the bladder 

 and urethra (male). 



By David I. Macht. 



[From the Pharmacological Laboratory and the Brady Urological 

 Institute, Johns Hopkins University.] 



In other communications dealing with the absorption of drugs 

 from the conjunctiva 1 and from the vagina, 2 published elsewhere, 

 the author called attention to the fact that apomorphin, by virtue 

 of its being a centrally acting emetic, furnishes a convenient means 

 of demonstrating absorption of drugs through unusual channels. 

 If a 1 per cent, solution of apomorphin hydrochloride is intro- 

 duced into the bladder of a male dog through a hard catheter, the 

 latter instrument being allowed to remain in place, the solution 

 remains in the bladder and owing to the powerful spasmodic 

 contraction of the urethral sphincter in che male dog, practically 

 none of the drug gets into the urethra. Under these circumstances 

 vomiting may occur not sooner than half an hour after the intro- 

 duction of the poison and sometimes after the lapse of an hour 



1 Jour. A. M. A., 1917, LXVIII, p. 1230. 



2 Jour, of Pharmacol, and Exp. Therap., Vol. X, 1918, p. 509. 



