58 



Scientific Proceedings (88). 



the daughters. The variation (mutation) has persisted through 

 four generations. 



143 (1321) 



Chemical pneumonia. 



By Martha Wollstein and S. J. Meltzer. 



[From the Laboratories of the Rockefeller Institute for Medical 

 Research, New York.] 



The use of chloramine T solution in the treatment of inflamma- 

 tions of the nose and throat suggested to us that the solution 

 might be useful in the curative treatment of pneumonia experi- 

 mentally produced in dogs. 



By intrabronchial insufflation of a definite dose per kilo of a 

 virulent pneumococcus culture, it was possible to cause a pneu- 

 monia which proved fatal to dogs in about 36 hours. Insufflation 

 of 5 c.c. per kilo of 1 : 10,000 solution of chloramine T in dogs 

 previously insufflated with pneumococci brought out the fact 

 that the treated dogs were harmed instead of benefited. The 

 chloramine T was then used alone in normal dogs. In doses of 

 5 c.c. per kilo of a 1 : 10,000 solution it produced consolidation 

 of the greater part of one or more lobes, with marked congestion 

 and edema of both lungs. Microscopically the lesion was a 

 broncho-pneumonia, with some intra-alveolar hemorrhage. Da- 

 kin's hypochlorite solution used in the same way caused a similar 

 lesion, even in dilutions of I : 20,000. Bichloride of mercury in 

 I : 10,000 solution produced rather more hemorrhage than the 

 chlorine compounds did. Cultures made from the consolidated 

 areas of all the lungs failed to grow. The pneumonia produced by 

 these chemical substances was sterile. 



