62 



Scientific Proceedings (88). 



the subject was given an antipyretic by mouth and the test was 

 repeated, generally about an hour later, but in some cases several 

 readings were repeatedly taken at definite intervals. The effect 

 of the following drugs was studied: Phenacetin, antipyrin, 

 acetanilid, quinine sulphate, pyramidon, aspirin and salol. In 

 addition to the study of individual drugs, the following combina- 

 tions were also administered: Acetanilid plus phenacetin, 5 grains 

 each; phenacetin plus salol, z\ grains each and 5 grains each; 

 aspirin and salol, 5 grains each; acetanilid and salol, 2\ grains 

 each and 5 grains each; and antipyrin and aspirin, 5 grains each. 

 The results of the experiments were not very striking. Briefly, 

 however, the effects of the drugs may be summarized as follows: 

 Phenacetin, acetanilid, antipyrine and quinine in the ordinary 

 doses (not exceeding 5 grains) showed a definite tendency to 

 improve the tapping rate. Larger doses of these drugs (8 or 

 more grains) tended to impair the efficiency of the test. The 

 improvement after phenacetin and antipyrin was greater than 

 that after acetanilid and quinine. After pyramidon, salol and 

 aspirin, no definite change could be noted as the different subjects 

 showed different results. Combinations of the various drugs 

 studied all showed a tendency to improve the tapping rate. This 

 was especially marked after the combinations of acetanilid and 

 salol and phenacetin and salol. 



