70 



Scientific Proceedings (89). 



weighing between nine and fifteen kilograms each were selected. 

 Both the fasting nitrogen elimination and the effect of glucose 

 feeding on this excretion were determined. During the fasting 

 period the animals received only 40 c.c. of water per kilo. On the 

 sugar days they received in addition 15 gm. of glucose per kilo. 

 An after-period during which the glucose feeding was withdrawn 

 was then introduced. Dr. Allen, of the Rockefeller Institute, 

 then removed surgically about 90 per cent, of the pancreas. The 

 wounds healed aseptically and the animals were allowed from two 

 to five weeks to recuperate. The procedure consisting of fore- 

 glucose and after-periods just described was repeated. In spite 

 of the large loss of pancreatic tissue the protein-sparing action of 

 glucose was not diminished in any of the animals. It appears 

 that pancreatic tissue is provided far in excess of actual require- 

 ments or that this gland is not solely responsible for the protein- 

 sparing action of carbohydrates. Dr. Ringer found this function 

 intact in dogs made completely diabetic by means of phlorizin. 



150 (1328) 



Studies in experimental shock. 



By T. S. Giteens and S. J. Meltzer. 



[From the Department of Physiology and Pharmacology of the 

 Rockefeller Institute for Medical Research.] 



The experiments were made on etherized dogs. The intestines 

 and stomach were dislocated and frequently handled. Two 

 manifestations were studied, the blood pressure and the pain sense. 

 We shall state merely the facts obtained. 



About one third of the dogs were given a preliminary injection 

 of morphin. Some of the animals were given ether by cone, others 

 by the method of intratracheal insufflation. These factors had 

 no apparent influence on the results. 



There were 42 dogs which received surgical narcosis. In 15 

 the blood pressure never reached a level below 95 mm. even when 

 the experiment lasted 4 hours or longer, and sensation returned as 

 soon as the animals came out of ether. In 13 dogs the blood 

 pressure reached a level below 70 mm. of mercury within two and 



