SCIENTIFIC PROCEEDINGS 



Abstracts of Communications. 

 Ninetieth meeting. 



Presbyterian Hospital, March 20, IQ18. 

 President Gies in the chair. 

 157 (1335) 



The rate of dialysis of diabetic blood-sugar. 



By Israel S. Kleiner. 



[From the Department of Physiology and Pharmacology of the 

 Rockefeller Institute for Medical Research.] 



Fifteen or twenty c.c. of blood, rendered incoagulable by dry 

 hirudin, were dialyzed in a very thin animal parchment bag 

 against 1,000 c.c. of Ringer's solution. To the Ringer's solution 

 was sometimes added a small percentage of dextrose in order to 

 retard the rate of dialysis. Bacterial growth was inhibited by the 

 addition of powdered thymol or by working at a low temperature. 

 Samples of blood for sugar analysis were taken at hourly intervals 

 and the rate at which the sugar passed from the blood into the 

 Ringer's solution was thus determined. 



The results show a striking difference between the diabetic 

 blood (from depancreatized dogs) and its control, normal dog blood 

 with enough added dextrose to give about the same percentage of 

 sugar as the diabetic. In the control a smooth curve is obtained, 

 i. e., the most rapid dialysis during the first hour, somewhat less 

 the second, and so on. The diabetic, however, exhibits a marked 

 slowing, or even a complete cessation, of dialysis usually during 

 the second hour, but at times this occurs at some other period 

 and there may even be two such periods in the course of a four- 

 hour dialysis. 



