104 



Scientific Proceedings (91). 



vations so far made, the hypophysis of the female is much larger 

 than that of the male, both in our thyroidless and control animals. 

 If this point is established by further study, it may account for 

 the fact that the ovary differentiates earlier than the testis. 



In one of our experimental animals, the thyroid regenerated, 

 and then hypertrophied. The animal underwent metamorphosis 

 a month before the normal time, and at a size about one third 

 normal. Its ovaries were in a stage of differentiation, much 

 further advanced than normal. Its hypophysis could not be 

 studied on account of poor fixation. 



The various other organs and ductless glands of the thyroidless 

 animals are being studied at this time. In general they are 

 all larger than normal, but we have not yet determined whether 

 there is present true hypertrophy or whether the size is merely 

 proportional to the size of the larvae which are larger than normal. 



172 (1350) 



Generalized analgesia in cats after exposure to a war gas 

 (CH 3 ) 2 S0 4 . 



By John Auer. 



[From the Department of Physiology and Pharmacology of the 

 Rockefeller Institute.] 



Procedure. — Cats were subjected to the action of dimethyl 

 sulphate fumes in a concentration of 4.5 to 10,000 of air for one 

 hour. The dimethyl sulphate, which is a liquid at ordinary tem- 

 peratures with a specific gravity of 1.32 and a boiling point of 

 1 88° C, was vaporized by an electric hot plate in the gas chamber. 

 An electric fan in the gas chamber kept the available fumes 

 mixed with the air. The temperature of the gas chamber was 

 maintained between 25-30 0 C. 



With this strength of gas the cats usually succumbed in 30-60 

 hours. 



In cats which are gassed as described above a strong generalized 

 analgesia is observed within a few hours after exposure to the 

 dimethyl sulphate fumes, and reaches a high degree within twenty- 

 four hours. If the animal survives, the analgesia may still be 

 well marked six months afterwards. 



