Acute Lobar Pneumonia. 



hi 



pronounced in capillary spaces. Conversely calcium chloride, 

 which causes an aggregating effect on soap films raises surface 

 tension and tends to diminish the permeability of emulsion sys- 

 tems to water, would tend to diminish the permeability of the 

 structure as a whole to an even greater extent when functioning 

 in capillary spaces. 



The above data correlates admirably with the well-known fact 

 that alkalis, salts of sodium, potassium, etc., promote the per- 

 meability of tissues while salts of calcium, magnesium, and other 

 di- and trivalent cations exert the reverse effect. Also with the 

 observations of Beebe and the writer regarding the high K content 

 and low Ca content of rapidly growing tumors and the low content 

 of K and high Ca content of slow-growing or stationary tumors. 



The experimental data on which this paper is based together 

 with a full development of the theoretical aspect of the case from 

 the standpoint of surface tension and tissue permeability will 

 shortly be published. 



176 (1354) 



The relationship of the leucocyte count and bone-marrow 

 changes in acute lobar pneumonia. 



By Robert A. Lambert and S. S. Samuels. 



[From the Pathological Laboratory of the Presbyterian Hospital, 



New York City.] 



It is well recognized that the leucocyte count in lobar pneu- 

 monia may vary within wide limits. The majority of the cases 

 which end fatally show either a very high or relatively low count, 

 while those with favorable outcome most often have counts be- 

 tween these extremes. 



For the low leucocyte count, at least two explanations have 

 been suggested: (1) the bone marrow fails to react, either as the 

 result of some previous injury (chronic alcoholism, for example), 

 or on account of a paralysis of the blood-forming elements from 

 overstimulation by the pneumococcus infection itself; (2) a rapid 

 spread of the pneumonic process takes the leucocytes out of the 

 blood faster than they are thrown into the circulation from the 

 bone-marrow, therefore, the number of circulating leucocytes may 



