114 



Scientific Proceedings (91). 



The musculature was remarkably free from all chronic changes, 

 which is all the more surprising in view of the frequency with 

 which acute changes have been described after intravenous injec- 

 tion of massive doses of streptococci. 



In seven of the animals there were thromboses in the blood 

 vessels of the lung, of which six were distinctly septic. Most of 

 these thromboses followed the injection of non-hemolytic strep- 

 tococci and they were most frequent after injection of the more 

 virulent types of these organisms. Besides these lesions which 

 were evidently produced by the injections, a considerable number 

 of the animals died of severe bronchial pneumonia. 



Seven rabbits developed renal lesions showing diffuse acute 

 and subacute glomerulitis, frequently associated with more or 

 less degeneration of the epithelium. No severe interstitial 

 changes were observed. Three of these animals had endocarditis 

 at the same time and three others amyloid degeneration. 



The liver of a great many of the animals was diseased, but on 

 account of the frequency with which rabbits suffer from coccid- 

 iosis it was impossible to determine whether any of the chronic 

 changes were due to the injections. Some of the animals showed 

 septic thrombi in the blood vessels and recent necroses of the 

 parenchyma which were evidently caused by them. 



The gall-bladder was infected in a great many rabbits and 

 some of these cases showed as a result acute cholecystitis; others 

 more chronic changes. Gall-stones were not found in any of the 

 cases. 



Fourteen cases showed pigmentation of the spleen or other 

 evidences of blood destruction. Ten rabbits showed amyloid 

 accumulations in the malpighian bodies. The earliest case of 

 amyloid occurred on the forty-fourth day. 



It is ot some interest to note that four rabbits at autopsy 

 showed an acute tonsillitis which however was probably due to 

 secondary infection. 



One of the rabbits developed an acute appendicitis and another 

 an acute ulcer of the stomach. One rabbit died of intussusception. 



Endarteritis was observed in four cases; in two ot these the 

 lesions were in the branches of the pulmonary artery; in one in the 

 aorta and in one in the branches of the coronary artery. The 

 lesions were comparatively recent and not very severe. 



