On Serum Proteins. 



115 



Examination of the central nervous system showed only slight 

 lesions in the pia in a few places. One of the rabbits died as the 

 result of an acute subdural hemorrhage. 



So far as the organs of special sense are concerned, a few rabbits 

 developed conjunctivitis, rhinitis and one otitis media. These 

 were all probably due to secondary infections. 



One rabbit developed a septic necrosis of the testicle; another 

 one accidentally received a fracture of the rib which was apparently 

 infected by way of the blood stream. 



In conclusion it may be stated that the streptococci did not 

 seem to exhibit any special affinity for the organ from which they 

 were isolated nor did any of the strains show any particular 

 affinity for special organs in the rabbits injected except for the 

 fact that the non-hemolytic group seemed to favor the heart valves. 



The details of these experiments will be published elsewhere bv 

 Dr. E. W. Smith. 



178 (1356) 



On serum proteins. 1 



By Lillian J. Ellefson and Carl L. A. Schmidt. 



[From the Hearst Laboratory of Pathology and Bacteriology and the 

 Department of Biochemistry of the University of California.] 



Intrapleural injections of aleuronat suspensions into rabbits 

 caused a marked rise of serum globulins and a consequent upset 

 of the protein quotient. Injection of ten cubic centimeters of 

 blood serum from these animals into normal rabbits did not pro- 

 duce appreciable changes in the serum proteins of the latter animals . 

 Apparently there is no factor concerned in the upset of the normal 

 protein quotient which can be transmitted by injection of such 

 homologous sera. 



Injection of ten cubic centimeters of 1 : 30,000 homologous 

 typhoid agglutinating serum intravenously into a normal rabbit 

 caused a very slight, non-persistant rise of globulins in the serum 

 of the injected animal. A normal rabbit which received ten cubic 

 centimeters of 1 : 7,000 homologous staphylococcus agglutinating 



1 Aided in part by a grant from the George Williams Hooper Foundation for 

 Medical Research. 



