Gastric and Duodenal Contents. 



137 



disturbed coordination. The chroma tolysis in these cells seems 

 to be roughly proportional to the intensity of symptoms. In 

 general, the cytoplasm and nuclei swell, often to several times the 

 normal size, the tigroid substance becomes faint and collected 

 around the nucleus, or disappears altogether. Often the entire 

 cell shrinks and disappears completely. In one dog with disturbed 

 motor function resulting from exposure to the vapor several 

 months before the sectioning of the brain no Purkinje cells at all 

 could be found in some parts of the cerebellum. All signs pointed 

 to a permanent lesion. A hen showed a similar permanent effect. 

 In these two cases the fatigued or weakened muscle activity in 

 the legs resembled closely the type said to be associated with 

 lesions of certain cerebellar tracts. 



Since the Purkinje cell axones are the only efferent paths from 

 the cerebellar cortex and since the nitrobenzene attacks these 

 cells especially, if not selectively, the results are suggestive. 

 While we cannot claim a specific and direct effect of nitrobenzene 

 on these cells, as far as chromatolysis may indicate it the action is 

 not much in evidence, if at all, in other parts of the nervous system. 



Animals poisoned in this way illustrate nicely cerebellar dis- 

 orders for teaching purposes. They also show in a striking way 

 an instance of delayed development of toxic action of a substance 

 stored in the body. This latent period in nitrobenzene poisoning 

 forms one of its most interesting features and is being studied by 

 the writers. Other interesting problems have been opened up by 

 the work. 



190 (1368) 



A method for the simultaneous fractional analyses of gastric and 

 duodenal contents. 



By Max Kahn. 



[From the Department of Laboratories, Beth Israel Hospital, New 



York.] 



It is possible to study simultaneously the duodenal and gastric 

 secretions by the following method : An Einhorn tube is passed into 

 the duodenum of the patient, using the technic of Einhorn. Next 



